Development of the human embryo is largely extrapolated from studies in animal models, particularly with the use of embryos from animal models such as wildtype and mutant mouse embryos. However, given species specific differences may occur in the developmental regulation of embryonic development, it is imperative to acquire primary data on human embryonic development to validate observations made in animal models. With human embryos obtained from the historic Carnegie collection, we generated an Atlas of the Human Embryo spanning Carnegie stage 13 to 23. Imaging was carried out using both high resolution magnetic resonance Imaging (MRI) and epsicopic fluorescence image capture (EFIC). The image stacks obtained are presented as 2D image stacks in three orthogonal imaging planes and also in 3D reconstructions. Annotations have also been made on selected anatomical structures as a teaching tool. More detailed delineation of the cardiovascular system is provided, some of which may be clinically useful for guiding early fetal ultrasound examination of high risk pregnancies with high suspicion of cardiovascular anomalies.
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