Apoptosis (programmed cell death) is one of the key processes that shape the developing organism as well as prevent cancer. The apoptotic cells are removed/engulfed in a non-immunogenic manner via specialized or neighboring cells. The orderly clearance of apoptotic cells prevents inflammation and autoimmune responses. To better understand the process of cell clearance, we developed a fluorescent genetic marker that can be used in cell culture and in live developing organisms. Our overall goal is to understand how tissues are generated, maintained, and dismantled by apoptosis and competing/complementary processes such as autophagy. While many genes have already been identified, many more that are necessary for cell clearance and processing of the cell corpses, the cascades that lead to the production of “find-me,” “eat-me,” and “don’t-eat-me” signals, as well as anti-inflammatory and immunosuppressant factors produced by the apoptotic cells are yet to be discovered.